Publication | Closed Access
Photocontrol of Tyrosine Phosphorylation in Mammalian Cells via Genetic Encoding of Photocaged Tyrosine
167
Citations
26
References
2012
Year
Molecular RegulationPhotobiologyMolecular BiologyPhotocaged TyrosineCellular PhysiologyReceptor Tyrosine KinasePhotosensitizersCell SignalingPhotochemistryBiochemistryMechanistic PhotochemistryMammalian CellsCell BiologyTyrosine PhosphorylationPhotoreceptor CellSignal TransductionNatural SciencesCellular BiochemistryMedicineGenetic Encoding
We report the first site-specific genetic encoding of photocaged tyrosine into proteins in mammalian cells. By photocaging Tyr701 of STAT1 we demonstrate that it is possible to photocontrol tyrosine phosphorylation and signal transduction in mammalian cells.
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