Concepedia

Stereoselective Synthesis of the Diazonamide A Macrocyclic Core

Ilga Mutule, Beomjun Joo, Zane Medne, Toms Kalniņš, Edwin Vedējs, Edgars Sūna

The Journal of Organic Chemistry · 2015 · 18 citations · 52 references

DOI

Concepts

Abstract

Stereoselective synthesis of the right-hand heteroaromatic macrocycle of diazonamide A features C16-C18 bond formation in the Suzuki-Miyaura cross-coupling and atropodiastereoselective Dieckmann-type macrocyclization as key steps. The Suzuki-Miyaura cross-coupling gave the best yields when it was catalyzed by a palladium-dioxygen complex.

References

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