Transethnic Replication of Association of CTG18.1 Repeat Expansion of<i>TCF4</i>Gene With Fuchs' Corneal Dystrophy in Chinese Implies Common Causal Variant

Abstract

Transethnic replication of the association between the CTG18.1 repeat expansion in the TCF4 gene and FECD suggests it is a common, causal variant shared in Eurasian populations conferring significant risk for the development of FECD. Our data suggest that the expanded CTG18.1 allele is the main, if not sole, causal variant at this gene locus in the Chinese population.