Evaluation of the Role of Routine Melan-A Immunohistochemistry for Exclusion of Microinvasion in 120 Cases of Lentigo Maligna

Abstract

We recommend use of melan-A to confirm the diagnosis in early lesions of LM and in the differential diagnosis from melanocytic hyperplasia in chronically sun-exposed skin. We do not recommend routine use of melan-A to identify or exclude microinvasion. However, it may have a role, in conjunction with S100, in cases with suspicious features for early invasion on haematoxylin and eosin sections.