A Free-Radical Cascade Methylation/Cyclization of <i>N</i>-Arylacrylamides and Isocyanides with Dicumyl Peroxide

Abstract

A free-radical cascade methylation/cyclization of a wide range of N-arylacrylamides and isocyanides is demonstrated by using dicumyl peroxide as the methylating reagent, which provides a convenient and selective access to various methylated N-heterocycles such as oxindoles and phenanthridines.