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Presence of Two Different Viral Agents in Brain Cells of Patients with Subacute Sclerosing Panencephalitis
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1970
Year
Measles-related VirusViral PathogenesisSusceptible CellsViral PersistenceBrain InjuryNeurologyNeuropathologyNeuroimmunologyNeurovirologyVirologyChronic Viral InfectionEncephalitisDifferent Viral AgentsSubacute Sclerosing PanencephalitisNeuroscienceVirus-host InteractionMultiple SclerosisMedicineBrain Cells
A measles-related virus was isolated from two out of three brain biopsies of patients with SSPE by the fusion of brain cells with susceptible cells. β-propiolactone-inactivated Sendai virus was used in the fusion experiments. The mechanism of activation and the characterization of the isolated agents are discussed. Their association with another virus is reported in light of the etiology of SSPE.