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Right-handed and Left-handed Double-helical DNA: Structural Studies
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1983
Year
X-ray CrystallographyDnaX-ray Diffraction PatternsDna AnalysisMolecular BiologyDna NanotechnologyNucleic Acid ChemistryProtein FoldingProtein X-ray CrystallographyLeft-handed Double-helical DnaDna ComputingNucleic Acid FibersBiochemistryOligonucleotideDna ReplicationCrystallographyStructural BiologyNatural SciencesMedicineFiber Diffraction Pattern
The availability of chemically synthesized oligonucleotides of defined sequence has changed the nature of nucleic acid structural studies from fibers to single-crystal X-ray analyses. Studies on nucleic acid fibers have intrinsic limitations because their X-ray diffraction patterns are of only limited resolution; the amount of structural information one can obtain from them is correspondingly limited. Solution of a fiber diffraction pattern makes it impossible to obtain many interesting structural details.