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Sensitivity of Mice to Endotoxin after Vaccination with BCG (Bacillus Calmette-Guerin)
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1958
Year
Bacillus Calmette-guerinToxinologyMicrobial PathogensHumoral ResponseImmunologyImmune SystemBacterial PathogensRepeated InjectionsSingle Intravenous InjectionMedical MicrobiologyInfection ControlE. Coli LipopolysaccharideMicrobial ToxinMucosal VaccinationHumoral ImmunityImmune FunctionClinical MicrobiologyVaccinationAntibioticsPathogenesisMedicine
1. It is shown that a single intravenous injection of BCG in mice induces a state of hyperreactivity to bacterial endotoxin. The LD50 for E. coli lipopolysaccharide is decreased from 357 μg in controls to 6 or 7 μg in BCG vaccinated animals. This change appears around the 5th day after vaccination. 2. Trehalose dimycolate, a component derived from virulent tubercle bacilli induces a similar state of hyperreactivity to endotoxin upon single or repeated injections.