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Pachysandra Alkaloids. VIII. Structures of Pachystermine-A and -B, Novel Type Alkaloids Having a β-Lactam Ring
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1967
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Pachysandra AlkaloidsBioorganic ChemistryBiochemistryβ-Lactam RingMedicineNatural SciencesNovel Type AlkaloidsHerbal MedicinePachysandra Terminalis SiebSecondary Metabolite20-Diamino-5α-pregnane AlkaloidWeakly Basic AlkaloidsPhytochemistryPharmacologySynthetic ChemistryDrug DiscoveryNatural Product Synthesis
Pachystermine-A (I) and -B (II), weakly basic alkaloids isolated from Pachysandra terminalis SIEB. et ZUCC.(Buxaceae), were investigated. The structures and stereochemistry of these alkaloids are now assigned to the formula I and II, respectively. They represent a novel type of 3, 20-diamino-5α-pregnane alkaloid carrying a four-membered β-lactam ring system.