Highly Efficient Assembly of 3-Hydroxy Oxindole Scaffold via a Catalytic Decarboxylative [1,2]-Addition Strategy

Abstract

The 3-hydroxy-2-oxindole scaffold is being continuously discovered to be at the core of a diverse set of natural products. Herein, we document a highly efficient catalytic decarboxylative [1,2]-addition strategy to quickly assemble this scaffold, using a catalytic amount of weak base.