Studies on bioactive substances in crude drugs used for arthritic diseases in traditional Chinese medicine. III. Isolation and identification of anti-inflammatory and analgesic principles from the whole herb of Pyrola rotundifolia L.

Abstract

Anti-inflammatory and analgesic principles were isolated from the methanol extract of the whole herb of Pyrola rotundifolia L., based on bioassays of the inhibitory activities on carrageenaninduced hind paw edema in rats and on acetic acid-induced writhing in mice. The principles were identified as ursolic acid and chimaphilin.