Highly Efficient Synthesis of (<i>R</i>)-3-Quinuclidinol in a Space–Time Yield of 916 g L^–1 d^–1 Using a New Bacterial Reductase <i>Ar</i>QR

Abstract

A new keto reductase (ArQR), identified from Agrobacterium radiobacter ECU2556, can efficiently reduce 3-quinuclidinone in excellent enantioselectivity and high space-time yield for the synthesis of (R)-3-quinuclidinol, a chiral building block of many antimuscarinic agents. This is the first time that a high yield of (R)-3-quinuclidinol up to 916 g L(-1) d(-1) using a bioreduction approach is reported.