A facile O-glycosidation using stannic chloride.

Abstract

Using stannic chloride, O-glycosidation, especially O-glucuronidation of p-nitrophenol, estradiol 17-acetate, estriol 16, 17-diacetate, p-nitrobenzyl alcohol, trichloroethanol was carried out. This method is available for the preparation of some alkyl α- and β-glucuronosides and aryl β-glucuronosides, especially estrogen derivatives which are obtained in comparatively low yield by the Koenigs-Knorr method. Spectral differences of α- and β-anomers obtained were examined.