Cellular Resistance in Tissue Culture, Induced by Noncytopathogenic Strains, to a Cytopathogenic Strain of Virus Diarrhea Virus of Cattle

Abstract

Three noncytopathogenic strains of virus diarrhea (VD) virus from cattle induced resistance to a plaque-forming strain of VD virus in agar overlay cell cultures of embryonic bovine kidney cells. Plaque inhibition made possible the measurement of virus concentration of noncytopathogenic VD virus strains. Cellular resistance was neutralized by VD virus antibodies.