On the Nature of Oxytocin and Vasopressin from Human Pituitary.

Abstract

SummaryThe oxytocic and pressor activities of the human posterior pituitary gland were separated chromatographically after preliminary purification. The behavior of purified components on ion exchange chromatography, paper chromatography and paper electrophoresis indicated that they possessed the properties of oxytocin and arginine vasopressin. The amino acid composition of the oxytocin and vasopressin isolated from the human glands was determined. It is evident that the oxytocin and vasopressin found in the human pituitary are identified as oxytocin and arginine vasopressin.