Mucopolysaccharide, Protein and Desoxyribosenucleic Acid Concentration of Granulation Tissue Induced by Polyvinyl Sponges.

Abstract

SummaryPolyvinyl sponges inserted under the dorsal skin of guinea pigs fill with cellular connective tissue. Dry weight of the granulation tissue, concentration of protein, desoxyribosenucleic acid and acid mucopolysaccharide at intervals between 1 and 12 weeks are reported. Both glucosamine and galactosamine were present in the mucopolysaccharide fraction. Evidence for the presence of 3 types of mucopolysaccharide components was obtained by chromatography and carbazole/orcinol ratios. A decrease in carbazole/orcinol ratios suggested an increased proportion of chondroitin sulfate B in the older granulomas.