Prevention of Histamine and Surgical Shock by Cortical Hormone (Desoxycorticosterone Acetate and Cortin) and Saline

Abstract

SummaryIn the prevention and treatment of histamine shock in rats and mice, parenteral saline combined with cortical hormone is more effective than either alone. The prophylactic effect of this combined treatment in raising resistance of rats and mice to histamine shock is much more pronounced than the therapeutic effect after histamine is administered. Application of these experimental observations to the prevention of surgical shock in human beings is reported.