Murine Nucleus Pulposus-Derived Cells Secrete Interleukins-1-β, -6, and -10 and Granulocyte-Macrophage Colony-Stimulating Factor in Cell Culture

Abstract

Cultured murine disc-derived cells have the capacity to secrete proinflammatory cytokines and interleukin-10 in the absence of inflammatory cells. This finding supports the hypothesis that disc-derived cells are capable of initiating or amplifying an inflammatory process.