Experimental Biology and Medicine · 1982 · 11 citations · 0 references
MedicineEndocrinologyPharmacologyNeuroendocrinologyReproductive EndocrinologyReproductive PhysiologyAdrenal HormonesGonadal Axis RegulationHormonal Regulation Of ReproductionOvarian PhysiologyReproductive NeuroendocrinologyRodent EndocrinologyAdrenergic SignalingAdrenergic TransmissionHypothalamic-pituitary-gonadal Axis RegulationLuteinizing Hormone ResponseLuteinizing Hormone SecretionNoradrenergic ModulationNoradrenergic NeurotransmissionOvarian Hormone Regulation
This study reveals that in OVX, estrogen-primed animals isoproterenol can interrupt a progesterone-induced LH surge already in progress and lower blood LH to control levels. The results support the notion that the noradrenergic influence may contain both α-adrenoceptor (stimulatory) and β-adrenoceptor (inhibitory) components and that an LH surge is triggered only when the balance is tipped in favor of the α-adrenoceptor component, presumably by the modulatory action of ovarian steroids.