Chemical and Pharmaceutical Bulletin · 1971 · 17 citations · 0 references
Life SciencesMolecular BiologyPharmacologyGene ExpressionRna ProcessingTranscriptionRna TranscriptionRna TurnoverIn Vivo StudiesPool Size EffectsPurificationRadioactivity Measurement
The in vivo administration of extract of the roots of Panax ginseng C. A. MEYER increased the incorporation rate of labeled precursors into liver nuclear RNA at 4 hr and into cytoplasmic polysomal RNA at 5.5-6.0 hr after a single dose intraperitoneal injection in a rat. The incorporation rate was directly dependent on the amount of a fraction obtained by partial purification. The increased specific radioactivity of the liver RNA is not due to the change in the pool size of endogenous acid-soluble nucleotides.