"Spontaneous" Leukemia Developing in G3H Mice Following Inoculation, In Infancy, with AK-Emkemic.

Abstract

Summary1. Seven of 14 C3H mice inoculated when less than 12 hours old with Ak leukemic extracts developed leukemia at 8 to 11 months of age. 2. Four of 6 C3H mice inoculated. when less than 12 hours old, with cell suspensions prepared from Ak embryos. developed leukemia at 8 1/2 months of age. 3. No leukemia resulted when mice more than 12 hours old were used for inoculation. 1. These experiments suggest that spontaneous mouse leukemia may be caused by an agent, which is transmitted from one generation to another, like that of chicken lymphomatosis.