Concepedia

sp<sup>3</sup> C–H Bond Activation with Ruthenium(II) Catalysts and C(3)-Alkylation of Cyclic Amines

Basker Sundararaju, Mathieu Achard, Gangavaram V. M. Sharma, Christian Bruneau

Journal of the American Chemical Society · 2011 · 176 citations · 39 references

DOI

Concepts

Abstract

A selective C(3)-alkylation via activation/functionalization of sp(3) C-H bond of saturated cyclic amines was promoted by (arene)ruthenium(II) complexes featuring a bidentate phosphino-sulfonate ligand upon reaction with aldehydes. This highly regioselective sustainable transformation takes place via initial dehydrogenation of cyclic amines and hydrogen autotransfer processes.

References

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