Enhancement of dissolution profile for oral delivery of Fexofenadine Hydrochloride by solid dispersion (solvent evaporation) technique

Abstract

The objective of present work is to investigate the enhancement of dissolution profile for oral delivery of Fexofenadine Hydrochloride (FH) through solid dispersion (SD) technique by the method of solvent evaporation. The SD was prepared by using ethanol as a solvent. Tablets were formulated containing solid dispersion of FH and compared with tablets of same formula without solid dispersion of FH. The using of ethanol to prepare solid dispersion found a significant effect on the dissolution of FH. Dissolution studies using the USP-33 paddle method were performed for tablets formulated with and without solid dispersions of FH. Dissolution of FH improved significantly in tablets formulated with SD (85% in 10 minutes) exhibited better dissolution profile than tablets formulated without SD. Infrared (IR) spectroscopy was also performed to identify the physicochemical interaction between drug and solvent, hence its effect on dissolution.