Taraxastane and Lupane Triterpenoids from the Bark of Manilkara zapota

Abstract

Aims: Discovering new lead compounds against cancer and bacterial infections is a crucial step to ensuring a sustainable global pipeline for new effective drugs.This study focus on the isolation of secondary metabolites of methanol extract from the bark of Manilkara zapota (Sapotaceae) a Cameroonian medicinal plant.Study Design: According to the literature, plants of the genus Manilkara are potential sources of antibacterial and anticancer secondary metabolites.Methodology: The air-dried and powdered bark (4.0 kg) of M. zapota was extracted at room temperature for 72 h with a methanol.The extract was concentrated to dryness under vacuum and the residue was subjected to repeated column chromatographic separation.The structures of the