Chlorpromazine Blockade of Water Imbibition by Frog Gastrocnemius

Abstract

1. The chlorpromazine-induced inhibition of water imbibition by frog gastrocnemius is unrelated to tranquilizing ability, adrenergic blockade, and antihistaminic activity. 2. Selected compounds exhibiting carbonic anhydrase inhibition, anticholinergic activity, analgetic and antiinflammatory activity, adrenergic activity, monamine oxidase inhibition, metabolic uncoupling, cholinesterase inhibition and high energy phosphate activity produce only minor or no inhibition of water uptake. 3. Correlation exists between block of water imbibition and loss of sodium and potassium from the muscle.