Cu-Catalyzed Arylcarbocyclization of Alkynes with Diaryliodonium Salts through C–C Bond Formation on Inert C_(sp3)–H Bond

Abstract

Copper-catalyzed arylcarbocyclization reaction of alkynes was realized with diaryliodonium salts through C-C bond formation on an inert C(sp3)-H bond. This method provides an efficient cyclization of alkyl alkynes to generate carbocycles with good step-economy. Theoretical study revealed an interesting Cu-catalyzed concerted pathway of the C-C bond formation.