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A Quantitative Difference in the Immune Response between Male and Female Mice
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1968
Year
Knockout MouseAllergyAutoimmune DiseaseLaboratory ImmunologyImmunologyProtein AntigenAutoimmunityEndocrinologyQuantitative DifferenceSex DifferenceReproductive BiologyImmune MediatorImmune SystemMedicineFemale MiceOvarian HormoneReproductive Hormone
SummaryThe immune response to a protein antigen (BSA, bovine serum albumin) was compared in male and female mice. It was found that female mice developed a stronger and longer lasting immune response and that female mice were more responsive to small doses of antigen. An explanation based on the effect estrogens have on phagocytosis is discussed.