Experimental Biology and Medicine · 1968 · 136 citations · 0 references
Life SciencesEndocrinologyImmunologyImmunophysiologyReproductive EndocrinologyReproductive ImmunologyAndrogen PhysiologyEndocrine Regulation Of ImmunityImmune PhysiologyMammalian ImmunologyRodent EndocrinologyRodent ImmunologyBovine Serum AlbuminEndocrine Disruptor Effects On ImmunityEstrogen ImmunomodulationSex Hormone InfluencesSex-based Differences In Susceptibility
The immune response to a protein antigen (BSA, bovine serum albumin) was compared in male and female mice. It was found that female mice developed a stronger and longer lasting immune response and that female mice were more responsive to small doses of antigen. An explanation based on the effect estrogens have on phagocytosis is discussed.