Role of Heparin in in vitro Production of Alpha1 Lipoproteins in Human Plasma

Abstract

1. An absolute increase in high-density alpha1 lipoproteins, and a concomitant decrease in certain low density lipoproteins, have been demonstrated by ultracentrifugal and chemical means. 2. These changes occurred in vitro in plasma obtained after heparin injections and suggest, on the basis of earlier studies on the nature of the lipemia-clearing reaction, an enzymatic conversion of one lipoprotein class to another.