Pathomechanism of Pain-Related Behavior Produced by Allografts of Intervertebral Disc in the Rat

Abstract

The nucleus pulposus and anulus fibrosus produce different forms of hyperalgesia (mechanical vs. thermal) associated with different and distinct immunohistochemical changes. It is possible that radicular pain of a lumbar disc herniation results from chemicals, such as phospholipase A2 and nitric oxide.