Recent Advances on Multicomponent Reactions Based on the Transamination Process of Electron Deficient Enamines

Abstract

Electron deficient enamines bear several different nucleophilic and eletrophilic sites in their structures, they can also serve as donors of CC bonds in organic reactions. Therefore, electron deficient enamines have been broadly employed in organic synthesis via various nucleophilic, electrophilic transformation and cycloaddition. Based on the research interest and works of our group in the chemistry of electron deficient enamines, the research advances on multicomponent reactions (MCRs) are reviewed based on the transamination of electron deficient enamines with ammomium, amines, enamines, ureas and thioureas as key transformation.