Bile Duct Apoptosis and Cholestasis Resembling Acute Graft-Versus-Host Disease After Autologous Hematopoietic Cell Transplantation

Abstract

Two recipients of autologous hematopoietic cells developed histologic abnormalities of small bile ducts and cholestatic liver disease resembling GVHD of the liver after allogeneic transplant. The mechanisms of bile duct damage in this setting may involve immune dysregulation related to reconstitution of immunity with peripheral blood stem cells.