Concepedia

Synthesis and antioxidative properties of some 3,4-dihydropyrimidin-2(1H)ones (-thiones)

Malahat Kurbanova, R. T. Abdinbekova, I. A. Rzaeva, M. A. Allakhverdiev

Russian Journal of Applied Chemistry · 2006 · 49 citations · 7 references

DOI

Concepts

Abstract

3,4-Dihydropyrimidinones (-thiones) were prepared by ternary condensation of various aromatic aldehydes with ethyl acetoacetate and urea (thiourea) in the presence of trichloroacetic acid in ethanol.

References

7

100 years of the biginelli dihydropyrimidine synthesis

C. Oliver Kappe · Tetrahedron · 1993 · 1.2K citations

, , +8

Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents

George C. Rovnyak, Karnail S. Atwal, Anders Hedberg et al. · Journal of Medicinal Chemistry · 1992 · 451 citations

, , +11

A Reexamination of the Mechanism of the Biginelli Dihydropyrimidine Synthesis. Support for an <i>N</i>-Acyliminium Ion Intermediate<sup>1</sup>

C. Oliver Kappe · The Journal of Organic Chemistry · 1997 · 449 citations

, , +13

A revision of the Biginelli reaction under solid acid catalysis. Solvent-free synthesis of dihydropyrimidines over montmorillonite KSF

Franca Bigi, Silvia Carloni, Bettina Frullanti et al. · Tetrahedron Letters · 1999 · 300 citations

, , +16

A solid phase protocol of the biginelli dihydropyrimidine synthesis suitable for combinatorial chemistry

Peter Wipf, April M. Cunningham · Tetrahedron Letters · 1995 · 230 citations

, , +14