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Selectivity in Reversed-Phase Liquid Chromatography Using Chemically Bonded Stationary Phases
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1974
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EngineeringSupercritical Fluid ChromatographyChemistrySolution (Chemistry)Separation ScienceGas ChromatographyAnalytical ChemistryLiquid ChromatographyPhase SeparationRelative SolubilityChromatographyMaterials ScienceBiochemistryMobile PhaseChemisorptionPhysical ChemistryChromatographic AnalysisDeep Eutectic SolventPhase EquilibriumStationary PhasesMedicineDrug Analysis
Selectivity in LC using nonpolar chemically bonded stationary phases is considered in terms of Everett's thermodynamic theory of adsorption. While the organic group bonded onto the siliceous support particle establishes solute functional group selectivity, individual compounds of a similar type are separated on the basis of their relative solubility in the mobile phase. It is possible to estimate small solubilities very simply using this type of LC.