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Interferon and Murine Leukemia. I. Inhibitory Effect of Interferon Preparations on Development of Friend Leukemia in Mice.
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1967
Year
Friend LeukemiaMixed-phenotype Acute LeukemiaImmunologyViral PathogenesisPathologyHigh TiterAntiviral DrugTumor BiologyHematological MalignancyMurine LeukemiaFriend VirusVirologyCell BiologyPathogenesisConcentrated PreparationsAntiviral ResponseAntiviral TherapyInterferon PreparationsVirus-host InteractionMedicineViral Immunity
Administration of concentrated preparations of interferon of high titer (extracted from either mouse brain or serum and spleen) inhibited the development of splenomegaly induced by Friend virus in Swiss and DBA2 mice. Interferon was effective only when treatment was continued daily throughout the duration of the experiment, and when inoculated mtraperitoneally (rather than intravenously).