Hypoxia enhances tenocyte differentiation of adipose‐derived mesenchymal stem cells by inducing hypoxia‐inducible factor‐1α in a co‐culture system

Abstract

Taken together, we found that growing ADMSCs under hypoxia, or activating expression of HIF-1α to be important in differentiation of ADMSCs, which provides a foundation for application of ADMSCs in vivo for tendon regeneration.