Concepedia

Publication | Closed Access

Glypican 3 Expression in Pediatric Malignant Solid Tumors

DOI

37

Citations

0

References

2014

Year

Sakura Tanaka, Ryota Souzaki, Kina Miyoshi, Kenichi Kohashi, Yoshinao Oda, Tetsuya Nakatsura, Tomoaki Taguchi, Yoshiaki Kinoshita
European Journal of Pediatric Surgery

Abstract

Most cases of hepatoblastoma and yolk sac tumor, and some cases of other tumors were found to express GPC3 either histologically or serologically. On the other hand, GPC3 was physiologically expressed during the fetal and neoinfantile period under 1 year of age. Although, more preliminary data and experience are required, patients older than 1 year that show a positive finding for GPC3 are considered to be appropriate candidates to receive the new immunotherapy using GPC3 peptide vaccination.