Green Conditions for Passerini Three-Component Synthesis of Tocopherol Analogues

Abstract

A Passerini three-component reaction of a furoxan aldehyde, phenylethylisocyanide, and trolox derivatives under green conditions are reported. The Passerini reaction to obtain tocopherol mimetics can be efficiently carried out either solvent-free or in aqueous conditions under microwave irradiation, which are standards of green chemistry and characteristic of an ideal synthesis.