Cyclo-Oxygenase-2 Knockout Genotype in Mice Is Associated With Blunted Angiotensin II-Induced Oxidative Stress and Hypertension

Abstract

Cyclo-oxygenase-2 pathway plays a major role in the superoxide generation as well as in the angiotensin II-induced oxidative stress and blood pressure. Cyclo-oxygenase-1 activity didn't show any influence on these parameters. These results suggest that cyclo-oxygenase-2 is involved in the pathogenesis of hypertension.