Effect of Colestipol (U-26,597A) on Experimental Atherosclerosis in Rabbits

Abstract

SummaryColestipol, a high-molecular-weight polymer which binds bile acids, exerts a hypocholesteremic effect in several species. The addition of 1% colestipol to an atherogenic regimen (2% cholesterol, 6% corn oil) did not significantly affect serum or liver cholesterol levels of rabbits but did cause a significant reduction (p < .05) in atheromata in both the aortic arch and thoracic aorta. An appreciable number of rabbits fed 1% colestipol were free of atheromata.We are indebted to Dr. T. M. Parkinson of the Upjohn Co., Kalamazoo, MI for generously supplying the colestipol used in this work.