American Journal of Clinical Pathology · 1988 · 34 citations · 0 references
MedicineHematologyPathologyGastroenterologyHemostasisInflammationCoagulation DisordersCoagulation Factor DeficienciesDeep Vein ThrombosisInflammatory Bowel DiseaseThrombosisThrombotic DisordersAcquired Coagulation DisordersCofactor Protein S DeficiencyEtiologic HypothesisInflammatory Bowel Disease ImmunopathogenesisInflammatory Bowel Disease PathologyProtein Deficiency StatesRare Bleeding DisordersRare Coagulation Factor Deficiencies
The authors observed a patient with severe inflammatory bowel disease (IBD) complicated by ten episodes of deep venous thrombosis (DVT). Her unusual thrombotic tendency prompted further investigation for primary hypercoagulability. A nonfamilial deficiency of Protein S was documented suggesting the deficiency was acquired. This occurrence suggests that low Protein S levels should be considered as a potential etiologic factor in patients with IBD and recurrent DVT.