Cobalt(II)-Catalyzed Oxidative C–H Alkenylations: Regio- and Site-Selective Access to Isoindolin-1-one

Abstract

Isoindolinone derivatives were prepared in a step-economical fashion by a C–H/N–H functionalization process with a catalytic system composed of Co(OAc)2 and Mn(OAc)2 or AgOPiv. The oxidative annulation by benzamides occurred efficiently with differently substituted electron-deficient alkenes. Mechanistic studies were indicative of a kinetically relevant, carboxylate-assisted C–H cobaltation.