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Synthesis of the metabolites and degradation products of 2-amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3-b)pyridine-3-carboxylic acid (Amoxanox).
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1985
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AsthmaOrganic ChemistryPharmacotherapyPharmaceutical ChemistryMedicinal ChemistryPharmacological StudyBronchial AsthmaDegradation ProductsPromising DrugAllergyBiochemistryPharmacologyNatural Product SynthesisInhalation ToxicologyPyridine-3-carboxylic AcidNatural SciencesMedicineSynthetic ChemistryDrug Discovery
The metabolites and degradation products of 2-amino-7-isopropyl-5-oxo-5H-[1] benzopyrano-[2, 3-b] pyridine-3-carboxylic acid (Amoxanox, AA-673, 1), a promising drug for the treatment of bronchial asthma, were synthesized to confirm the proposed structures and to determine their activity in the rat passive cutaneous anaphylaxis test.