Demonstration of Antibodies in Acquired Hemolytic Anemia With Anti-Human Globulin Serum

Abstract

The erythrocytes of 2 patients with acquired hemolytic anemia and spherocytosis have been shown to be readily agglutinated by an immune rabbit serum containing an anti-human globulin antibody. Since both patients have exhibited abnormal hemolytic activity for transfused cells this finding is compatible with the existence of an immune body type of hemolytic agent as the cause of the accelerated hemolysis.