Iron-Catalyzed N-Alkylation of Azoles via Cleavage of an sp³C–H Bond Adjacent to a Nitrogen Atom

Abstract

Iron-catalyzed direct C-N bond formation between azoles and amides is described. The oxidative coupling reactions of sp(3) C-H bonds adjacent to a nitrogen atom in amides and sulfonamides with the N-H bond in azoles proceeded smoothly in the presence of FeCl(2) and di-tert-butyl peroxide (DTBP).