Cold Spring Harbor Symposia on Quantitative Biology · 1979 · 143 citations · 0 references
Life SciencesGeneticsMicrobiologyBacteriologyDna ReplicationMicrobial GeneticsMicrobial Genome ReplicationPlasmid ReplicationReplication In ProkaryotesReplication InitiationReplication OriginsBacterial Chromosome ReplicationBacterial Dna ReplicationEscherichia ColiGenetic Map ConstructionOric Replication OriginReplication Initiation In BacteriaReplication Origins In Prokaryotes
Replication of the circular chromosome of Escherichia coli (Cairns 1964) is bidirectional (Masters and Broda 1971; Bird et al. 1972; Prescott and Kuempel 1972). Replication appears to be initiated at a fixed site (Marsh and Worcel 1977) which has been located about 20 megadaltons (MD) counterclockwise of the ilv operon (von Meyenburg et al. 1977) at 82.5 minutes on the genetic map (Bachmann et al. 1976). For this site, the origin of replication of the chromosome, the symbol oriC has been introduced (Hiraga 1976).