Synthesis of new cephamycin derivatives and a novel rearrangement between isothiazolethioacetamides and 1,3-dithietanecarboxamides.

Abstract

A novel intramolecular rearrangement of isothiazolethioacetamides into 1, 3-dithietanecarboxamides is described, together with the synthesis of a new cephamycin derivative (YM-09330) having a 1, 3-dithietane structure at the 7β-position. This compound showed strong antibacterial activity, especially against gram-negative organisms.