Impaired Monocyte IL-12 Production Before Surgery as a Predictive Factor for the Lethal Outcome of Postoperative Sepsis

Abstract

These results identify a selective preoperative defect in monocyte IL-12 production as a predictive factor for the lethal outcome of postoperative sepsis. These data suggest that a partial preoperative monocyte paralysis severely impairs the host defense against postoperative infection, resulting in an increased risk of lethal sepsis.