Ouabain Induces Nitric Oxide Release by a PI3K/Akt-dependent Pathway in Isolated Aortic Rings From Rats With Heart Failure

Abstract

Results demonstrate that low ouabain concentration can decrease vascular reactivity of aortic rings from HF rats. Ouabain was able to increase nitric oxide production in HF rats by triggering a signal transduction PI3K/Akt-dependent pathway and increasing an endothelium-hyperpolarizing factor release.