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Effect of Total-Body X-Irradiation on Relative Turnover of Nucleic Acid Phosphorus.
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1952
Year
Radiation EffectCpna Specific ActivityRadiation ExposureMolecular BiologyRadiation BiologyNucleic Acid PhosphorusOxidative StressRelative TurnoverHepatotoxicityRadiation OncologyRadiation ChemistryNuclear MedicineHealth SciencesBiochemistryLiver PhysiologyNuclear PnaPhysiologyCpna SynthesisMetabolismMedicineTotal-body X-irradiation
The incorporation of P32 into DNA; nuclear PNA (nPNA), and cytoplasmic PNA (cPNA) of liver was measured in rats which had been exposed to 2500r total body X-irradiation and in mice which had been exposed to 600r total body X-irradiation. It was found that the incorporation of P32 into cPNA was increased in all cases, while into DNA and nPNA it was depressed. In the Sprague-Dawley rats an increase in the weights of the liver was observed concurrent with the increase in cPNA specific activity. A possible interrelationship between protein and cPNA synthesis has been discussed.