Complete Regression of Lymphosarcoma Implants Following Temporary Induction of Riboflavin Deficiency in Mice.

Abstract

Marked regression of established lymphosarcoma (6 C3H-ED) implants occurred in all of 48 C3H mice rendered temporarily deficient in riboflavin either by the feeding of a diet low in this vitamin or by the administration of an antagonist. In most cases survival was significantly prolonged and 15 mice survived without recurrence of the tumors for more than 200 days. When animals which had survived 60 days or more were reinoculated with lymphosarcoma tissue, the second implant failed to take. Established lymphosarcoma implants in 81 control mice on a diet supplemented with adequate amounts of riboflavin, grew continuously and killed all animals within about 4 weeks.